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Abstract #4581

Proton MRS of Hepatic Ischemia/Reperfusion Injury in an Experimental Rat Model

April M. Chow1,2, Kannie W.Y. Chan1,2, Shu Juan Fan1,2, Jerry S. Cheung1,2, Ed X. Wu1,2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR, China

Hepatic ischemia/reperfusion injury (IRI) occurs during liver transplantation, tumor resection, hemorrhagic shock and veno-occlusive disease. Biochemical changes caused by hepatic IRI lead to hepatocellular remodeling, including cellular regeneration or irreversible programmed cell death. In this study, we demonstrated that the alteration in the metabolism of choline-containing compounds (CCC) accompanied with hepatic IRI could be monitored using 1H MRS. The CCC peak may be useful in evaluating the regeneration of hepatocytes upon hepatic IRI. 1H MRS has shown to be a potential tool for identify and quantify metabolic changes in liver in vivo noninvasively.