April M. Chow1,2, Kannie W.Y. Chan1,2,
Shu Juan Fan1,2, Jerry S. Cheung1,2, Ed X. Wu1,2
1Laboratory of Biomedical Imaging and
Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR,
China; 2Department of Electrical and Electronic Engineering, The
University of Hong Kong, Pokfulam, Hong Kong SAR, China
Hepatic
ischemia/reperfusion injury (IRI) occurs during liver transplantation, tumor
resection, hemorrhagic shock and veno-occlusive disease. Biochemical changes
caused by hepatic IRI lead to hepatocellular remodeling, including cellular
regeneration or irreversible programmed cell death. In this study, we
demonstrated that the alteration in the metabolism of choline-containing
compounds (CCC) accompanied with hepatic IRI could be monitored using 1H
MRS. The CCC peak may be useful in evaluating the regeneration of hepatocytes
upon hepatic IRI. 1H MRS has shown to be a potential tool for
identify and quantify metabolic changes in liver in vivo noninvasively.
Keywords