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Abstract #4603

Long-Range Diffusion of Hyperpolarized 3He in Normal and Emphysematous Rat Lungs

Ignacio Rodriguez1,2, Laura Carrero-Gonzalez, 1,3, Thomas Kaulisch3, Detlef Stiller3, Jose Manuel Perez-Sanchez4, Jesus Ruiz-Cabello1,2

1Instituto de Estudios Biofuncionales, Universidad Complutense, Madrid, Spain; 2CIBER de Enfermedades Respiratorias, Madrid, Spain; 3Boehringer Ingelheim Pharma, Biberach an der Riss, Germany; 4Univ. Paris-Sud, CNRS, Orsay, France

Using long-range diffusion MRI, ADC of rats with induced emphysema in one lobe has been performed. The results show a statistically significant increase of ADC in the emphysematous lobe at breath-hold, whereas no significant difference is seen at end expiration. Collateral ventilation could play a role in these results. The increase seen at breath-hold agrees with the results found by other workers.