Meeting Banner
Abstract #4602

Evaluation of Global Surface-To-Volume Ratio of Rabbit Lung Using Hyperpolarized 129Xe Uptake Spectroscopy at 1.5T

Yulin Chang1, Jaime F. Mata1, Talissa Altes1, John P. Mugler III1, Kai Ruppert1

1Radiology, University of Virginia, Charlottesville, VA, United States

Hyperpolarized xenon-129 dissolves into lung tissue and binds hemoglobin and the dissolved-phase (DP) xenon molecules exchange with the gas-phase molecules via diffusion. Therefore the initial rate of the signal replenishment of the DP xenon following a saturation is proportional to both square root of time and lung surface area. In this work we demonstrate the possibility of measuring lung surface-to-volume ratio using DP xenon signals at short delays after a complete saturation in a rabbit model.