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Abstract #4635

R2* as a Surrogate Measure of Ferriscan Iron Quantification in Thalassemia

Wesley Calvin Chan1, Faisel Budhani1, Zahra Tejani1, Christine Massey2, Masoom A. Haider1

1Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; 2Dalla Lana School of Public Health, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, ON, Canada

Monitoring hepatic iron concentration is an important clinical concern in thalassemia patients. The aim of this study is to demonstrate a correlation between R2* relaxation rate and liver iron concentration determined by the FDA approved Ferriscan method. We found a very strong linear correlation between R2* values and Ferriscan determined liver iron concentration with the Spearman correlation = 0.976 (95% CI: 0.963, 0.984). The prediction equation from regression analysis was ([Fe])=0.80(R2*)-44.1(r=0.968, r2 = 0.937, p < 0.0001). Determination of liver iron concentration by R2* methods may be helpful as a diagnostic surrogate for Ferriscan iron measurements.