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Abstract #4636

Chronic Hepatitis and Fibrosis Assessed by Magnetic Resonance Elastography (MRE)

Yi Wang1, Frank H. Miller1, Robert McCarthy, Zongming E. Chen, Laura Sternick, Daniel Ganger, Richard Ehman2, Reed Omary1, Josh Levitsky, Bradley D. Bolster, Jr. 3, Saurabh Shah3, Sven Zuehlsdorff3, Paul Nikolaidis1, Vahid Yaghmai1

1Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States; 2Mayo Clinic; 3Siemens Healthcare

We proposed to evaluate the capability of MRE in detecting and distinguishing patients with inflammation and without fibrosis from patients without inflammation and fibrosis, and with various stages of fibrosis based on histopathologic analyses. Liver tissue with inflammation and without fibrosis can be seen with mildly elevated stiffness value on MRE, which was significantly higher than those that lack inflammation and fibrosis. Both mild hepatic fibrosis and inflammation was associated with mild elevation of stiffness, but a significant difference was not observed. Furthermore, tissue with moderate fibrosis and advanced fibrosis to cirrhosis showed significant increased stiffness values on MRE.