Michael Alexander Fischer1, Paul Stolzmann1, Daniel Nanz1, Ccilia S. Reiner1, Stefan Breitenstein2, Matteo Montani3, Borut Marincek1, Hans Scheffel1
1Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland; 2Clinic of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland; 3Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
A new approach for absolute quantification of liver fat content is presented by calculation of fat volume fractions (FVF-MRI) derived from a single-breathhold 3D spoiled dual gradient-echo MRI sequence yielding for in-/out-of-phase as well as fat-signal only images. Our results show that the absolute liver fat content equalling the actual weight per volume of liver lipid can be quantified accurately by FVF-MRI with surface-coil sensitivity correction compared to fat volume fractions derived from histopathology as the gold standard. Moreover fat-only images significantly reduce the measurement bias as compared to in/out-of-phase images.