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Abstract #4646

Absolute Quantification of Liver Fat by MRI Fat Volume Fractions in Comparison to Histopathology

Michael Alexander Fischer1, Paul Stolzmann1, Daniel Nanz1, Ccilia S. Reiner1, Stefan Breitenstein2, Matteo Montani3, Borut Marincek1, Hans Scheffel1

1Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland; 2Clinic of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland; 3Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland

A new approach for absolute quantification of liver fat content is presented by calculation of fat volume fractions (FVF-MRI) derived from a single-breathhold 3D spoiled dual gradient-echo MRI sequence yielding for in-/out-of-phase as well as fat-signal only images. Our results show that the absolute liver fat content equalling the actual weight per volume of liver lipid can be quantified accurately by FVF-MRI with surface-coil sensitivity correction compared to fat volume fractions derived from histopathology as the gold standard. Moreover fat-only images significantly reduce the measurement bias as compared to in/out-of-phase images.