Michael Alexander Fischer1, Paul Stolzmann1,
Daniel Nanz1, Ccilia S. Reiner1, Stefan Breitenstein2,
Matteo Montani3, Borut Marincek1, Hans Scheffel1
1Institute of Diagnostic Radiology,
University Hospital Zurich, Zurich, Switzerland; 2Clinic of
Visceral and Transplant Surgery, University Hospital Zurich, Zurich,
Switzerland; 3Institute of Surgical Pathology, University Hospital
Zurich, Zurich, Switzerland
A
new approach for absolute quantification of liver fat content is presented by
calculation of fat volume fractions (FVF-MRI) derived from a
single-breathhold 3D spoiled dual gradient-echo MRI sequence yielding for
in-/out-of-phase as well as fat-signal only images. Our results show that the
absolute liver fat content equalling the actual weight per volume of liver
lipid can be quantified accurately by FVF-MRI with surface-coil sensitivity
correction compared to fat volume fractions derived from histopathology as
the gold standard. Moreover fat-only images significantly reduce the
measurement bias as compared to in/out-of-phase images.
Keywords