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Abstract #4650

Multislice Multiecho T2* MRI Assessment of Regional Pancreatic Iron Overload and Correlation with Cardiac Biventricular Function and Myocardial Iron Overload in Thalassemia Major Patients.

Gennaro Restaino1, Antonella Meloni2, Alessia Pepe2, Vincenzo Positano2, Massimiliano Missere1, Pasquale Pepe2, Daniele De Marchi2, Giuseppina Secchi3, Antongiulio Luciani4, Giuseppina Sallustio1, Massimo Lombardi2

1Catholic University, Campobasso, Italy; 2MRI Lab, G. Monasterio Foundation and Institute of Clinical Physiology, CNR, Pisa, Italy; 3Azienda USL n 1, Sassari, Italy; 4Istituto di Radiologia Az. Osp. "Garibaldi", Catania, Italy

The aims of this study were to describe the T2* values of the pancreas in patients with TM, to investigate the correlation between pancreatic and myocardial siderosis and to investigate the correlation between pancreatic iron overload and biventricular cardiac function. The mean T2* over the pancreatic head was significantly higher than the mean T2* value over the pancreatic body and tail. Significant positive correlations of the pancreatic T2* were demonstrated for global heart T2* value and number of segments with normal T2*. Moreover, pancreatic iron overload was negatively correlated to biventricular systolic function.