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Abstract #4651

The Use of Slope-Ratio Methods to Quantify Liver Perfusion from Dynamic Contrast-Enhanced MR Data: Comparison with Perfusion Quantification Using a Dual-Input Single Compartment Model

Keiko Miyazaki1, Matthew R. Orton1, James A. d'Arcy1, Val Lewington2, Dow-Mu Koh3, Martin O. Leach1, David J. Collins1

1CR-UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom; 2Department of Nuclear Medicine, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; 3Department of Radiology, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

Dynamic contrast-enhanced (DCE-) MRI is a technique that enables non-invasive interrogation of tissue microvasculature environment. Different analysis approaches can be taken to quantify arterial and portal-venous hepatic perfusion from liver DCE-MRI data. In this study, two slope-ratio methods were used to quantify arterial and portal-venous perfusion from clinical MR data. Comparisons were made with perfusion quantified using a dual-input single compartment model. Perfusion quantified using the slope-ratio methods were found to be lower than those quantified using the dual-input model. High correlations were observed between the two approaches, especially in the estimates of arterial perfusion.