Edmund Mark Godfrey1, Anant S. Krishnan1,
Susan E. Davies2, Nyree M. Griffin3, Graeme J.
Alexander4, Mike E. Allison4, Alexander E. Gimson4,
William H. Griffiths4, David J. Lomas1
1Department of Radiology, Addenbrooke's
Hospital, Cambridge, Cambridgeshire, United Kingdom; 2Department
of Histopathology, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United
Kingdom; 3Department of Radiology, St Thomas' Hospital, London; 4Department
of Hepatology, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United
Kingdom
Standard
imaging techniques are insensitive to liver fibrosis. Current clinical
assessment of liver fibrosis requires a biopsy, which risks complications and
sampling error. This work describes our experience with 2 new MR techniques:
MR elastography and 31P spectroscopy. MR elastography was found to correlate
with histological grade of fibrosis in contrast to 31P PME/PDE ratio. Our
findings do not correlate with previous work. This may be because
histological grade in our study was based on the original report, rather than
review of the biopsy material. We plan to repeat the analysis of our results
with this data.
Keywords