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Abstract #4659

Evaluation of Nonalcoholic Liver Disease Using 23Na MRI and Shift Reagent-Aided 23Na and 31P MRS

Paige Nicole Hopewell1,2, Navin Bansal1,2

1Radiology, Indiana University School of Medicine, Indianapolis, IN, United States; 2Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States

Changes in signal intensity with disease progression in single quantum (SQ) and triple quantum-filtered (TQF) 23Na MRI are validated with shift reagent-aided SQ and TQF 23Na and 31P MRS studies in a nonalcoholic fatty liver disease model. Changes in intracellular Na+ concentration and fibrosis-associated macromolecule deposition in the extracellular space both contribute to an increased TQF 23Na MRI signal with advanced disease progression.