Paige Nicole Hopewell1,2, Navin Bansal1,2
1Radiology, Indiana University School
of Medicine, Indianapolis, IN, United States; 2Weldon School of
Biomedical Engineering, Purdue University, West Lafayette, IN, United States
Changes
in signal intensity with disease progression in single quantum (SQ) and
triple quantum-filtered (TQF) 23Na MRI are validated with shift
reagent-aided SQ and TQF 23Na and 31P MRS studies in a
nonalcoholic fatty liver disease model. Changes in intracellular Na+
concentration and fibrosis-associated macromolecule deposition in the
extracellular space both contribute to an increased TQF 23Na MRI
signal with advanced disease progression.