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Abstract #4665

Colonic Response to an Experimental Model of Human Diarrhoeal Disease

Elisa Placidi1, C. L. Hoad1, L. Marciani2, R. C. Spiller2, P. A. Gowland1

1SPMMRC, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom; 2Nottingham Digestive Diseases Centre Biomedical Research Unit, University of Nottingham, Nottingham, United Kingdom

MRI was used to investigate the colonic response to two contrasting test meals: a readily absorbable glucose drink (control) and a non absorbable mannitol drink, which acts as a model of acute diarrhoeal disease. Eight healthy volunteers were imaged on a 1.5 T Philips Achieva scanner with several sequences up to 8 hours after the drink, to assess changes in the ascending colon in terms of water content, volume, and image signal intensity. Differences between the two conditions have been quantified. A scoring system based on subjective assessment of colonic contents has also been developed.