Jeff Lei Zhang1, Henry Rusinek1,
Hersh Chandarana1, Pippa Storey1, Eric E. Sigmund1,
Pierre Hugues Vivier1,2, Qun Chen1, Hua Guo1,
Vivian S. Lee1
1Department of Radiology, New York
University, New York, NY, United States; 2Rouen University
Hospital, Rouen, France
In
this study we used a Monte Carlo simulation approach to explore the mechanism
of BOLD R2* contrast in kidney. Kidney pO2 levels predicted based on R2*
values by the simulation were in agreement with literature values for a
healthy volunteer, and correlated well with pO2 values measured by microprobe
for diabetic rats of a previous study. The results indicate that the approach
is a promising tool for quantifying kidney oxygenation level based on BOLD
data.