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Abstract #4681

Functional Renal Imaging with BOLD: Validation of a Model for R2* in Kidney Cortex and Medulla

Jeff Lei Zhang1, Henry Rusinek1, Hersh Chandarana1, Pippa Storey1, Eric E. Sigmund1, Pierre Hugues Vivier1,2, Qun Chen1, Hua Guo1, Vivian S. Lee1

1Department of Radiology, New York University, New York, NY, United States; 2Rouen University Hospital, Rouen, France

In this study we used a Monte Carlo simulation approach to explore the mechanism of BOLD R2* contrast in kidney. Kidney pO2 levels predicted based on R2* values by the simulation were in agreement with literature values for a healthy volunteer, and correlated well with pO2 values measured by microprobe for diabetic rats of a previous study. The results indicate that the approach is a promising tool for quantifying kidney oxygenation level based on BOLD data.