Effect of Octreotide on Intra-Renal Oxygenation as Estimated by BOLD MRI in Rats

Lu-Ping Li¹, Joann Carbray¹, Pottumarthi V. Prasad¹

Previous observations have shown lower intra-renal oxygenation as early as two days after induction of type I diabetes. In order to test the hypothesis that this may be related to the direct effect of hyperglycemia, the infusion of glucose solution was used in healthy rats. However comparable levels of blood glucose levels and R2* values in diabetic rats were observed only in animals pretreated with an insulin inhibitor (octeotride). Because octeotride is associated with vasoconstriction, it is necessary to know the magnitude of any direct effect of octeotride on renal oxygenation. That was the motivation for the present study.