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Abstract #4684

Long Term Follow-Up of Human Transplanted Kidneys by DWI and BOLD Imaging

Peter Vermathen1, Tobias Binser1, Chris Boesch1, Ute Eisenberger2, Harriet C. Thoeny3

1Dept. Clinical Research, University Bern, Bern, Switzerland; 2Dept. of of Nephrology and Hypertension, University Hospital of Bern, Bern, Switzerland; 3Dept. of Radiology, University Hospital of Bern, Bern, Switzerland

Previously, we performed a DWI and BOLD MRI study in renal allograft recipients with good allograft function and determined short term reproducibility of diffusion and oxygenation parameters. In the current study, nine patients of our initial study were measured again 322 months after the initial scan to assess long term effects on diffusion parameters and on R2*. The functional parameters were markedly stable after 32 months with a slight tendency towards reduced oxygenation in eight of the nine patients, who still had good allograft function. In contrast, one subject with decreased GFR indicative of renal dysfunction demonstrated strongly altered MR-parameters.