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Abstract #4701

Loss of Renal Diffusion Anisotropy in Patients with Chronic Kidney Disease

Yu-Chun Lin1,2, Koon-Kwan Ng1, Tzung-Hai Yen3, Yu-Min Chen3, Hsiang-Yang Ma2, Jiun-Jie Wang4

1Department of Diagnostic Radiology, ChangGung Memorial Hospital, KweiShan, Taoyuan, Taiwan; 2Department of Electrical Engineering, ChangGung University, KweiShan, Taoyuan, Taiwan; 3Department of Nephrology, ChangGung Memorial Hospital, Taiwan; 4Department of Medical Imaging and Radiological Science, ChangGung University, KweiShan, Taoyuan, Taiwan

Diffusion Tensor Imaging in kidney for patients with chronic kidney disease indicated a significant reduction of diffusion anisotropy. Images from 6 CKD patients and 6 normal subjects were acquired in a 3 Tesla MR scanner. Regions of interest were located bilaterally in medulla and cortex. The results showed decreases in diffusion anisotropy and associated increase in radial diffusivity, noticeably in medulla in patients. We concluded that renal DTI is feasible in 3T MR scanner and furthermore, sensitive to changes in diffusivities in patients with chronic kidney disease.