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Abstract #4700

Diffusion Weighted Imaging with Biexponential Analysis of Intravoxel Incoherent Motion in Assessment of Renal Lesions: Preliminary Experience

Hersh Chandarana1, Vivian S. Lee1, Elizabeth Hecht1,2, Bachir Taouli1,3, Eric E. Sigmund1

1Radiology, NYU Langone Medical Center, New York, NY, United States; 2Radiology, University of Pennsylvania, United States; 3Radiology, Mount Sinai Medical Center, New York, NY, United States

Movement of blood in microvasculature can be modeled as pseudo-diffusion also known as intravoxel incoherent motion. Perfusion effect can be separated if diffusion imaging is performed with low and high b values. The purpose of our study was to calculate perfusion fraction (fp) and tissue diffusivity (Dt) parameters obtained with biexponential analysis of multi-b DWI and determine if these parameters can distinguish enhancing from non-enhancing renal lesions. fp was higher and Dt lower in enhancing renal lesions; both these parameters had higher accuracy in detection of enhancing renal lesion compared to apparent diffusion coefficient (ADC) obtained with monoexponential fit.