Abstract #4705

ADC Measurements in the Evaluation of Lymph Nodes in Patients with Non-Hodgkin Lymphoma

Thomas Kwee¹, Inge Ludwig², Cuno Uiterwaal³, Henritte Quarles van Ufford¹, Marc Bierings⁴, Rob Fijnheer⁵, Taro Takahara¹, Rutger-Jan Nievelstein¹

¹Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands; ²Department of Hematology, University Medical Center Utrecht, Utrecht, Netherlands; ³Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; ⁴Department of Pediatric Hematology, University Medical Center Utrecht, Utrecht, Netherlands; ⁵Department of Hematology, Meander Medical Center, Amersfoort, Netherlands

This study aimed to investigate whether apparent diffusion coefficient (ADC) measurements allow discriminating normal lymph nodes from lymphomatous lymph nodes, and indolent lymphomas from aggressive lymphomas in patients with non-Hodgkin lymphoma (NHL). To that end, 18 healthy volunteers and 22 patients with newly diagnosed NHL (indolent: n=9; aggressive: n=13) prospectively underwent diffusion-weighted imaging at 1.5 T. Our results suggest that ADC measurements may be a highly specific method for discriminating normal lymph nodes from lymphomatous lymph nodes in patients with NHL. However, ADC measurements appear to be of no utility in differentiating indolent from aggressive lymphomas.