Nina Tunariu1, James A. d'Arcy, Veronica A.
Morgan1, Michael Germuska, Catherine G. Simpkin, Sharon L. Giles2,
David J. Collins, Nandita M. deSouza
1 CR-UK and EPSRC Cancer Imaging
Centre, Institute of Cancer Research and Royal Marsden Hospital, Sutton,
Surrey, United Kingdom; 2CR-UK and EPSRC Cancer Imaging Centre,
Institute of Cancer Research and Royal Marsden Hospital, United Kingdom
A
major challenge for implementing diffusion-weighted magnetic resonance
imaging (DW-MRI) as tumour response biomarker in multicentre clinical trials
is in measuring changes in individual patients reliably and reproducibly. The
delineation of the region of interest (ROI) has a great impact on final
reproducibility. This study compares ADC values obtained using in-house
computer ROI drawing software (Diffusion View) to segment tumour with those
obtained from a manual drawing technique. Computer generated ROIs have the
advantage of less variability, operator independence and significant time
saving and support the feasibility of use of automated DWI measurements in
clinical trials.