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Abstract #4729

A Simple Approach for Improving Lipid SNR for Hepatic Fat Measurement with 1H MRS

Giulio Gambarota1, Mark Tanner1, Johanna Berg2, Robert V. Mulkern3, Rex D. Newbould1

1GlaxoSmithKline, London, United Kingdom; 2Radiology, University Hospital of Malm, Sweden; 3Radiology, Children's Hospital Boston, Boston, MA, United States

Magnetic resonance spectroscopy (MRS) is becoming the method of choice for non-invasive assessment of lipids in liver. To avoid artifacts due to liver motion, MRS is often performed with a breath-hold approach. Given the limited amount of time available to perform the acquisition, it is of interest to maximize the signal-to-noise ratio (SNR) of the lipid resonances. Here, we show that it is possible to substantially improve the SNR of the in liver, by choosing an appropriate TR. The current approach has the advantage of experimental simplicity and can be applied to all basic sequences routinely used in clinical settings.