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Abstract #4730

Proton MRS of Changes of Lipid Unsaturation During Liver Regeneration

Kannie W. Y. Chan1,2, April M. Chow1,2, Shu Juan Fan1,2, Ed X. Wu1,2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR, China

Post-operative diagnosis is important in partial hepatectomy (PHx) to determine the best time for interventions or therapeutic measures. We studied changes in unsaturated lipids verse saturated lipids as a mean to follow liver regeneration. The amount of unsaturated lipid at different time points showed a related trend with liver regeneration. A high level was found at 24h post-PHx, and was correlated with the maximum liver regeneration, and the saturated lipid stayed at a high level during the first day of regeneration. Thus, this pilot study shows that 1H-MRS could provide us with more information on the degree of regeneration.