Susan M. Noworolski1,2, Kyle Kuchinsky3, Michelle Nystrom1, John Kurhanewicz1,2, Daniel B. Vigneron1,2, Peter R. Carroll4, Kirsten Greene4, Jeffry Simko3
1Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States; 2The Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA, United States; 3Pathology, University of California, San Francisco, CA, United States; 4Urology, University of California, San Francisco, CA, United States
Validation of MR measures of the prostate are challenging due to heterogeneity. Tissue compositions by histopathology and their impact on DCE MRI measures were evaluated and compared in high and moderate grade prostate cancers. Fourteen men had DCE MRI before prostatectomy. High Gleason Grade (≥4+4) lesions had higher %cancer than Gleason 3+3 lesions (87% vs. 58%, p<0.00001). Normalizing DCE MRI measures to %cancer led to higher measures versus healthy peripheral tissues and greater separations between 3+3 and 4+4 cancers. Heterogeneity of tissues and %cancer may impact DCE MRI measures, with potentially different effects in Gleason Grade 3+3 versus 4+4 cancers.