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Abstract #4741

Shutter-Speed Model Dynamic Contrast-Enhanced MRI to Reduce Unnecessary Surgeries of Atypical Breast Lesions: A Preliminary Study

Luminita Alina Tudorica1, Stephanie Hemmingson1, Karen Oh1, Arpana Naik1, Sunitha Thakur2, Elizabeth A. Morris2, Mark Kettler1, Ian J. Tagge1, Jason A. Koutcher2, Charles S. Springer1, Wei Huang1

1Oregon Health & Science University, Portland, OR, United States; 2Memorial Sloan Kettering Cancer Center, New York, NY, United States

Three of 28 core needle biopsy-proven high-risk atypical breast lesions were upgraded to malignancies following surgical excisions as standard care. Correlations with pre-biopsy quantitative DCE-MRI results show that the Shutter-Speed Model (SSM) analyses of DCE-MRI data discriminate the atypical lesions between those completely benign and those containing malignancies with high accuracy. SSM DCE-MRI can potentially be used to reduce unnecessary surgeries of atypical lesions.