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Abstract #4742

Characterizing Suspicious Lesions with MR Guided Diffuse Optical Breast Imaging

Colin Morehouse Carpenter1,2, Shudong Jiang2, Steven P. Poplack3, Roberta M. diFlorio-Alexander3, Brian William Pogue2, Keith David Paulsen2

1Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United States; 2Thayer School of Engineering at Dartmouth, Hanover, NH, United States; 3Radiology, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States

Breast MR has high sensitivity, yet suffers from comparatively low specificity. Optical imaging may aid MR mammography by providing spatial maps of disease-specific tissue properties such as total hemoglobin, oxygen saturation, water content, and tissue microstructure scatter, which have been shown in several studies to offer high specificity to malignant cancer. A multimodality MR-guided optical breast imaging instrument (MRg-OBI) has been developed and validated through numerous phantom and healthy volunteer studies. This study examined the ability of MRg-OBI in characterizing malignant from benign lesions in five patients. The results show that total hemoglobin is a good indicator of malignancy, with tumor to background contrast varying greatly from 1.25 up to 8.0, compared to less than 1 for the benign/fully responded lesions.