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Abstract #4748

Effects of Temporal Resolution on Breast Cancer Diagnostic Accuracy by Quantitative Dynamic Contrast-Enhanced MRI

Ian J. Tagge1, Xin Li1, Luminita Alina Tudorica1, Yiyi Chen1, Stephanie Hemmingson1, Elizabeth A. Morris2, Charles S. Springer1, Wei Huang1

1Oregon Health & Science University, Portland, OR, United States; 2Memorial Sloan Kettering Cancer Center, New York, NY, United States

High temporal-resolution research DCE-MRI data from 66 suspicious breast lesions were resampled to mimic typical clinical protocols with low temporal-resolution. The Standard Model (SM) and Shutter-Speed Model (SSM) pharmacokinetic analyses show that both Ktrans and Ktrans [ Ktrans(SSM) C Ktrans(SM)] are significantly underestimated at the lower temporal resolution, and the diagnostic accuracies of both parameters are considerably compromised.