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Abstract #4749

Fat Water Ratio and Diffusion-Weighted MRI Applied to the Measure of Breast Density as a Cancer Risk Biomarker

Ted Trouard1,2, Patricia Thompson3, Chuan Huang4, Maria Altbach2, Matthew Kupinski2, Denise Roe3, Kimberly Fitzpatrick2, Per Granstrom2, Georgette Frey3, Scott Squire2, Veronique Poulin3, Alison Stopeck3

1Biomedical Engineering, University of Arizona, Tucson, AZ, United States; 2Radiology, University of Arizona, Tucson, AZ, United States; 3Arizona Cancer Center, University of Arizona; 4Mathematics, University of Arizona

Breast density, as measured by mammography, is associated with elevated risk of breast cancer. Decreases in mammographic breast density have also been linked with beneficial effects of chemoprevention. However, the low precision and reproducibility of mammography, as well as exposure to ionizing radiation, limits the use of mammographic breast density as a biomarker for risk and prevention. In this study we have employed Fat Water Ratio (FWR) MRI for assessment of breast density and compared the results to conventional mammography and to apparent diffusion coefficients (ADCs) measured by diffusion-weighted (DW) MRI.