Abstract #4749

Fat Water Ratio and Diffusion-Weighted MRI Applied to the Measure of Breast Density as a Cancer Risk Biomarker

Ted Trouard^1,2, Patricia Thompson³, Chuan Huang⁴, Maria Altbach², Matthew Kupinski², Denise Roe³, Kimberly Fitzpatrick², Per Granstrom², Georgette Frey³, Scott Squire², Veronique Poulin³, Alison Stopeck³

¹Biomedical Engineering, University of Arizona, Tucson, AZ, United States; ²Radiology, University of Arizona, Tucson, AZ, United States; ³Arizona Cancer Center, University of Arizona; ⁴Mathematics, University of Arizona

Breast density, as measured by mammography, is associated with elevated risk of breast cancer. Decreases in mammographic breast density have also been linked with beneficial effects of chemoprevention. However, the low precision and reproducibility of mammography, as well as exposure to ionizing radiation, limits the use of mammographic breast density as a biomarker for risk and prevention. In this study we have employed Fat Water Ratio (FWR) MRI for assessment of breast density and compared the results to conventional mammography and to apparent diffusion coefficients (ADCs) measured by diffusion-weighted (DW) MRI.