Hon Yu1, Jack Hsu1, Ke Nie1, Muqing Lin1, Siwa Chan2, Jeon-Hor Chen1,2, Rita S. Mehta3, Orhan Nalcioglu1, Min-Ying Lydia Su1
1Center for Functional Onco-Imaging, University of California, Irvine, CA, United States; 2Department of Radiology, China Medical University Hospital, Taichung, Taiwan; 3Department of Medicine, University of California, Irvine, CA, United States
The suggested association between the chemotherapy-induced ovarian suppression and a positive prognostic impact for more favorable treatment outcome in pre-menopausal women with breast cancer was investigated. Using the enhancement values of DCE-MRI measured from the fibroglandular tissue of contralateral normal breast as a measure of ovarian suppression effect, our retrospective study indicates a possible prognostic value of such measurement via an association between an early onset of chemotherapy-induced ovarian suppression and positive treatment outcomes among the younger group of women (< 55 yr.). The observed association between early onset of reduced perfusion and poor treatment outcome among the older group of women ( 55 yr.) may represent an additional potential of the prognostic value in treatment-induced effects measured from the normal breast.