Beathe Sitter1, Mariann Gjervik Heldahl1,
Tone Frost Bathen1, Anna Bofin2, Steinar Lundgren1,3,
Ingrid Susann Gribbestad1
1Department of Circulation and Medical
Imaging, Norwegian University of Science and Technology, Trondheim, Norway; 2Department
of Laboratory Medicine, Children's and Women's Health, Norwegian University
of Science and Technology, Trondheim, Norway; 3Department of
Oncology, St. Olavs University Hospital
In vivo and ex vivo 1H MR spectroscopic data were obtained prior
to treatment from 19 patients assigned to neoadjuvant chemotherapy. Comparing
findings obtained in vivo and ex vivo showed that concentrations of
total choline (tCho) determined by ex
vivo MRS were significantly higher in tissue from patients with
detectable tCho by in vivo MRS
compared to those without detectable choline by in vivo MRS. We also found that patients with complete response
to treatment had significantly higher levels of GPC (p=0,037) than patients
not having complete response.
Keywords