Abstract #4752

Role of Choline as a Biomarker of Cell Proliferation to Differentiate HER2/neu Positive and Negative Breast Cancers Patients

Naranamangalam R. Jagannathan¹, Rani G. Sah¹, Uma Sharma¹, Rajinder Parshad²

¹Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; ²Department of Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India

The choline concentration and tumor volume were determined using in-vivo MRS and MRI in 53 invasive ductal carcinoma patients at 1.5 T with known HER2/neu status. The tCho concentration for HER2/neu positive cases was 4.8 3.3 mmol/kg which was statistically significantly higher compared to HER2/neu negative cases (2.7 0.7 mmol/kg; p=0.007). However, the tumor volume for the Her2/neu positive cases (47.956.1) and negative cases (45.648.3) were similar (p=0.84). The increase in tCho concentration observed in Her2/neu positive patients may be attributed to the high proliferative activity of the Her2neu positive tumors.