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Abstract #4753

Choline as a Biomarker a Better Predictor of Early Response of Breast Cancer Than Tumor Volume? Sequential Study of the Therapeutic Response of Locally Advanced Breast Cancer Patients Undergoing Neo-Adjuvant Chemotherapy (NACT)

R. G. Sah1, U. Sharma1, R. Prashad2, N. R. Jagannathan1

1Departmet of NMR and MRI facility, All India Institute of Medical Sciences, New Delhi, India; 2Departmet of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India

We report here that tCho concentration as a useful biomarker for early prediction of tumor response compared to tumor volume. tCho and volume were calculated in 30 locally advanced breast cancer patients undergoing NACT using MRS and MRI. In clinical responders, pre-therapy tCho was 5.1 (0.48) mmol/kg which significantly decreased to 2.6 (0.51) after I NACT and showed gradual decrease thereafter, while volume showed significant decrease only after II NACT. Reduction in tCho and tumor volume after I NACT was 39.8% and 6.5% respectively in responders. Non-responders showed an increase of tCho by 52.9% and 7% reduction in volume.