Meeting Banner
Abstract #4756

Impact of T1 Estimate Variation on DCE-MRI Derived Pharmacokinetic Values in Rectal Tumours

Moreno Pasin1,2, Gloria Castellazzi1, Paul Summers2, Roberto Di Filippi2, Luke Bonello2, Giuseppe Petralia2, Massimo Bellomi2

1Struttura Complessa di Radiologia/Diagnostica per immagini, Istituto Neurologico IRCCS- Fondazione Casimiro Mondino, Pavia, Lombardia, Italy; 2Radiology, Istituto Europeo di Oncologia, Milan, Lombardia, Italy

Variability in two-point T1 estimation may lead to uncertainty in derived DCE parameters. We examined the impact of T1 estimate noise on Ktrans, Kep, Ve, using two, low flip angle scans combined with a single dynamic DCE measurement and ROI definition in 9 rectal adrenocarcinoma patients at pre- and post- neoadjuvant treatment examinations. Ktrans and Ve variations attributable to T1 estimates were less than 5%, though variability in Ve may be exaggerated by peristaltic motion. The variation in Kep was not value dependent. We recommend the use of an aniperistaltic agent for rectal DCE to reduce variation in Ve.