Giuseppe
Petralia1, Paul Summers1, Luke Bonello1,
Stefano Viotti1, Roberto Di Filippi1, Laura Traviani2,
Maria Giulia Zampino3, Dow-Mu Koh4, Maria Cristina
Leonardi5, Antonio Chiappa6, Massimo Bellomi1
1Radiology,
Istituto Europeo di Oncologia, Milan, Lombardia, Italy; 2Nuclear
Medicine, Istituto Europeo di Oncologia, Milano, Italy; 3Medical
Care Unit, Department of Medicine, Istituto Europeo di Oncologia, Milan,
Lombardia, Italy; 4Radiology, Royal Marsden Hospital, Sutton,
United Kingdom; 5Radiotherapy, Istituto Europeo di Oncologia,
Milan, Lombardia, Italy; 6General and Laparoscopic Surgery,
Istituto Europeo di Oncologia, Milan, Lombardia, Italy
Functional
imaging techniques have potential in monitoring neoadjuvant chemoradiation
therapy and predicting therapy outcome in locally advanced rectal cancers. We
compared four different functional modalities (DCE-MR, DW-MR,CTp and PET) in
patients with locally advanced rectal cancer who underwent imaging with all
modalities before and after neoadjuvant treatment. From our small patient
population we observed a correlation between Kep and PS, both estimates of
capillary permeability (R=0.93), and a trend to correlation between Ktrans
and PS (R= 0.47), whereas negative correlations were observed between Ktrans
and SUV (R=-0.78), Ve and SUV (R=-0.86), and a negative trend for ADC and SUV
(R=-0.50).
Keywords