Dynamic Contrast Enhanced MRI Post-Prostatectomy for a Rising PSA: Implications for Radiotherapy

Radka Stoyanova¹, Raj Rajpara¹, Elizabeth Bossart¹, Victor Casillas², Jill Palma¹, May Abdel-Wahab¹, Alan Pollack¹

We present analysis of Dynamic Contrast-Enhanced Magnetic Resonance Imaging for identification of local recurrence of prostate cancer in men who underwent radical prostatectomy and had a subsequent rising Prostate-Specific Antigen (PSA). Our results indicate that we can detect abnormalities suggestive of residual tumor in the prostate bed in nearly 75% of patients evaluated for radiation therapy (RT). Because patients treated with salvage RT often develop a rising PSA later and there is some evidence for a RT dose response, targeting of the contrast-enhancing areas specifically may improve tumor control and limit toxicity.