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Abstract #4768

Dynamic Contrast Enhanced MRI Post-Prostatectomy for a Rising PSA: Implications for Radiotherapy

Radka Stoyanova1, Raj Rajpara1, Elizabeth Bossart1, Victor Casillas2, Jill Palma1, May Abdel-Wahab1, Alan Pollack1

1Radiation Oncology, University of Miami, Miami, FL, United States; 2Diagnostic Radiology, University of Miami, Miami, FL, United States

We present analysis of Dynamic Contrast-Enhanced Magnetic Resonance Imaging for identification of local recurrence of prostate cancer in men who underwent radical prostatectomy and had a subsequent rising Prostate-Specific Antigen (PSA). Our results indicate that we can detect abnormalities suggestive of residual tumor in the prostate bed in nearly 75% of patients evaluated for radiation therapy (RT). Because patients treated with salvage RT often develop a rising PSA later and there is some evidence for a RT dose response, targeting of the contrast-enhancing areas specifically may improve tumor control and limit toxicity.