Yuxi Pang1,2, Baris Turkbey2, Marcelino Bernardo, 23, Wei Liu, 2,4, Vijay Shah, 23, Peter Choyke2
1Philips Healthcare, Cleveland, OH, United States; 2Molecular Imaging Program, National Cancer Institute, Bethesda, MD, United States; 3SAIC-Frederick, Frederick, MD, United States; 4Philips Research North America, Briarcliff Manor, NY, United States
Intravoxel incoherent motion (IVIM) MR imaging has the potential to separate perfusion (active blood microcirculation) from pure diffusion in DWI studies. This perfusion information is intrinsically linked with angiogenesis in tumor growth, thus, it is expected that different perfusion patterns would be found in tumors in comparison to normal tissues. In this retrospective study, we have analyzed 22 DWI data from patients with prostate cancers, and found significant increases in IVIM-related perfusion in tumors. This result suggests that the DWI-derived perfusion be a possible surrogate biomarker and a potential additional MRI parameter for accurate diagnosis of prostate cancer.