Abstract #4779

T2-Weighted MR Imaging Combined with Diffusion Weighted MR Imaging for Selection of True Active Surveillance Patients Based on Stage and Gleason Score Criteria: A Retrospective Multireader Study.

Caroline Hoeks¹, Pieter Vos¹, Diederik Somford², Derya Yakar¹, Thomas Hambrock¹, Stijn Heijmink¹, Jurgen Futterer¹, Henk Vergunst³, Christina Hulsbergen-van de Kaa⁴, Fred Witjes², Henkjan Huisman¹, Jelle Barentsz¹

¹Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; ²Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; ³Department of Urology, Canisius Wilhelmina Hospital, Nijmegen, Gelderland, Netherlands; ⁴Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands

Problem Undersampling of prostate cancer can lead to incorrect surveillance (AS) patient selection. Aim: to determine if T2-weighted (T2w) MRI and diffusion weighted MRI (DWI) could contribute in AS patient selection by comparing radiologist reading of stage and Gleason score(GS) to prostatectomy. Methods Twelve prostatectomy patients were retrospectively selected by biopsy criteria and a performed 3T MRI preprostatectomy. Four radiologists scored T2w-MRI and T2w-MRI in combination with DWI. Results AUC values for T2w-MRI prediction of AS patients varied from 0,812 for inexperienced reader to 0,812-1,0 for experienced readers. Conclusion T2w-MRI could be of additional value in AS patient selection.