Fiona M. Fennessy1, Sota Oguro1,
Yi Tang1, Robert V. Mulkern1, Steven Haker1,
Ehud J. Schmidt1, Sandeep Gupta2, Clare M. Tempany1
1Radiology, Brigham and Women's
Hospital, Boston, MA, United States; 2GE Global Research,
Niskayuna,, NY, United States
Newer
approaches for prostate cancer treatment mandate improvements in MR imaging
to allow for accurate index lesion detection and display, to guide biopsy and
focal therapy. In 9 pathology-proven prostate cancer patients, we manually
segmented tumor according to multiparametric MR (mpMR) sequences using
3D-slicer software, and obtained volumetrics for each. Volumes based on DCE
maps were significantly greater than those based on ADC maps (p=0.011) or
T2WI (p=0.001), possibly reflecting different physiological properties of
tumor assessed with mpMR. Volume discrepancies can be displayed in a single
framework, and should be taken into consideration for tumor mapping in focal
therapy planning.
Keywords