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Abstract #4784

MR-US Fusion for Targeted Prostate Biopsy

Clifford Weiss1, Michael Seitz2, Karin Herrmann3, Arno Graser3, Berthold Kiefer4, Martin Requardt4, Jens Fehre4, Ralf Nanke4, Mamadou Diallo5, Parmeshwar Khurd5, Ali Kamen5, Wolfgang Wein5

1Center Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2Urology Department, Ludwig Maximilian Universitt Mnchen, Mnchen, Germany; 3Radiology Department, Ludwig Maximilian Universitt Mnchen, Mnchen, Germany; 4Siemens Healthcare, Erlangen, Germany; 5Imaging & Visualization Department, Siemens Corporate Research, Princeton, NJ, United States

We aim to improve prostate targeted biopsy procedures, by taking pre-acquired diagnostic MRI images, and actively fusing them to the real-time trans-rectal ultrasound. In this way the diagnostic power of prostate MRI is married to the flexible, rapid and inexpensive ultrasound guided procedure. We propose a system based on a magnetically tracked freehand ultrasound probe, combined with a novel powerful deformable registration workflow that effectively compensates prostate organ deformation between the two modalities. We present initial results in terms of registration accuracy and clinical usefulness, from a study on 19 middle aged patients with elevated PSA and suspected prostate cancer.