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Abstract #4788

Activation of Choline Kinase and Phospholipase C in HDAC Inhibition

Christopher S. Ward1, Judy Hwang1, Sabrina M. Ronen1

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

The aim of this study is to examine the modulation of choline metabolism by SAHA through a combination of magnetic resonance spectroscopy and enzymatic studies. This study confirmed previous findings of increased choline-related metabolites following HDAC inhibition, while providing new insight into the underlying mechanism. HDAC inhibition was associated with increases in choline kinase and phosphatidylcholine-specific phospholipase C activities, suggesting phosphocholine levels are elevated as a result of upregulation in both synthesis and catabolism.