Mary E. Loveless1,2, Jane Halliday3,
Carsten Liess4, Lei Xu5, Richard Dortch, 2,6,
Jennifer Whisenant, 2,7, John C. Waterton4, John C.
Gore, 2,6, Thomas E. Yankeelov, 2,6
1Biomedical Engineering, Vanderbilt
University, Nashville, TN, United States; 2Institute of Imaging Science, Vanderbilt University,
Nashville, TN, United States; 3Imaging, Translational Sciences,
AstraZeneca, Macclesfield , Cheshire, United Kingdom; 4Imaging,
Translational Sciences, AstraZeneca, Macclesfield, Cheshire, United Kingdom; 5Biostatistics,
Vanderbilt University, Nashville, TN, United States; 6Radiology
and Radiological Science, Vanderbilt University, Nashville, TN, United
States; 7Chemical & Physical Biology, Vanderbilt University,
Nashville, TN, United States
In
the quantitative analysis of DCE-MRI data, the contrast agent concentration
time course in the blood plasma (AIF) is required. In this study we compare
parameters resulting from two common DCE-MRI models driven by both individual
and population derived AIFs in mice for two different contrast agents,
Gd-DTPA and P846. The goal is to
determine how the individual and population AIF derived parameters compare
and how this affects the number of animals that would be needed in a given
study.