Gilberto S. Almeida1,2, Ian Wilson1,2,
Lance Farr3, Ross J. Maxwell1,2
1Northern Institute for Cancer
Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United
Kingdom; 2Newcastle Magnetic Resonance Centre, Newcastle
University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; 3Osteotronix
Ltd, Swansea, United Kingdom
The
aim of this study was to estimate the dimensions of vascular features in
animal tumour models (HT29 colon carcinomas in mice) using a combination of
structural spectroscopy analysis and contrast agent uptake. Structural
spectroscopy data were acquired from rectangular prisms across the tumour
using a one-dimensional spin-echo pulse sequence at 7T. The signal profiles
were analyzed to determine the size distribution of the anatomical elements
of interest before and 10 min after injection of gadoteridol. There was a
clear difference in the intensity of structural features (dimensions 10-20
mm-1) after injection of contrast agent.
Keywords