Gilberto S. Almeida1,2, Ian Wilson1,2, Lance Farr3, Ross J. Maxwell1,2
1Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; 2Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; 3Osteotronix Ltd, Swansea, United Kingdom
The aim of this study was to estimate the dimensions of vascular features in animal tumour models (HT29 colon carcinomas in mice) using a combination of structural spectroscopy analysis and contrast agent uptake. Structural spectroscopy data were acquired from rectangular prisms across the tumour using a one-dimensional spin-echo pulse sequence at 7T. The signal profiles were analyzed to determine the size distribution of the anatomical elements of interest before and 10 min after injection of gadoteridol. There was a clear difference in the intensity of structural features (dimensions 10-20 mm-1) after injection of contrast agent.