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Abstract #4814

Dynamic Contrast-Enhanced T1 -Weighted Perfusion MRI Differentiates Tumor Recurrence from Radiation Necrosis: Relative Cerebral Blood Volume Measurements and FDG-PET Validation

Vibeke Andre Larsen1, Helle Juhl Simonsen2, Ian Law3, Henrik Pedersen2, Henrik BW Larsson2, Adam Espe Hansen2

1Dept. of Radiology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark; 2Functional Imaging Unit, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark; 3PET and Cyclotron Unit, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

The use of perfusion MRI for tumor characterization is complicated by the blood brain barrier deficiency. This preliminary study provides evidence that dynamic contrast enhanced T1 weighted perfusion imaging can distinguish radiation-induced necrosis from tumor recurrence. We studied 9 patients after radiation treatment for gliomas and the results were validated with the FDG-PET gold standard. For 10 contrast enhancing lesions, 2 metabolically inactive lesions had relative cerebral blood volume (rCBV) of less than 1.7, whereas 8 active lesions had rCBV greater than 2.0.