Abstract #4820

Multimodality Characterization of a Bone-Metastasis Model

Dmitri Artemov¹, Kristy L. Weber², Yoshinori Kato¹, Wenlian Zhu¹, Zaver M. Bhujwalla¹

¹JHU ICMIC Program, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; ²Department of Orthopedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Metastasis is the leading cause of mortality from cancer. For several cancers, the bone is a major site of bulk disease from metastasis. While multimodality imaging of subcutaneous preclinical tumor models are becoming fairly routine, the application of multi-modality imaging to bone-metastasis models is a challenge. However, multi-modality imaging of such models can provide a wealth of information on the microenvironment, vasculature, and metabolism of bone metastasis that can used to improve treatment outcome and identify new strategies for treatment. Here we present multi-modal imaging characterization of a well-established bone metastasis model.