Dmitri Artemov1, Kristy L. Weber2,
Yoshinori Kato1, Wenlian Zhu1, Zaver M. Bhujwalla1
1JHU ICMIC Program, The Russell H. Morgan
Department of Radiology and Radiological Science, The Johns Hopkins
University School of Medicine, Baltimore, MD, United States; 2Department
of Orthopedic Surgery, The Johns Hopkins University School of Medicine,
Baltimore, MD, United States
Metastasis
is the leading cause of mortality from cancer. For several cancers, the bone is a major
site of bulk disease from metastasis.
While multimodality imaging of subcutaneous preclinical tumor models
are becoming fairly routine, the application of multi-modality imaging to
bone-metastasis models is a challenge.
However, multi-modality imaging of such models can provide a wealth of
information on the microenvironment, vasculature, and metabolism of bone
metastasis that can used to improve treatment outcome and identify new
strategies for treatment. Here we
present multi-modal imaging characterization of a well-established bone
metastasis model.