Louis Dore-Savard1,2, Luc Tremblay3,4,
Melanie Archambault3,4, Jean-Franois Beaudoin3,4,
Nicolas Beaudet1,2, Eric E. Turcotte3,4, Roger Lecomte3,4,
Philippe Sarret1,2, Martin Lepage3,4
1Physiologie et biophysique, Universite
de Sherbrooke, Sherbrooke, Quebec, Canada; 2Centre des
Neurosciences de Sherbrooke, Sherbrooke, Quebec, Canada; 3Mdecine
nuclaire et radiobiologie, Universite de Sherbrooke, Sherbrooke, Quebec,
Canada; 4Centre d'imagerie molculaire de Sherbrooke, Sherbrooke,
Quebec, Canada
A
better understanding of the mechanisms underlying the genesis of bone cancer
pain is clearly needed. We used a multimodal imaging protocol combining
μCT and MRI-PET co-registration in a novel murine bone cancer pain
model. Interestingly, we consistently detected bone tumor before pain
behavior were observable. Moreover, MRI, Na18F and 11C-methionine PET
provided us with complementary information allowing the visualization of
compensative bone formation, inflammation, tumor metabolism and extensive
damage in bone microenvironment. This model and our imaging approach will
help the understanding of metastatic bone pain and facilitate the development
of improved analgesic therapy.
Keywords