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Abstract #4823

Monitoring Metastases in a Mouse Model of Ewings Sarcoma Using DWIBS

Cornelius Faber1, Marc Hotfilder2, Sareeta Kailayangiri2, Hendrik Kooijman3, Uta Dirksen2, Claudia Rssig2, Volker Vieth1

1Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany; 2Department od Pediatric Hematology and Oncology, University Hospital Muenster; 3Philips Health Care

Diffusion-weighted Whole-body Imaging with Body background signal Suppression (DWIBS) was implemented in a mouse model of Ewings Sarcoma on a clinical 3 T scanner. Metastasis formation could be detected and monitored over a period of four weeks. 3D MIP reconstruction of DWIBS data allowed for fast identification of metastases and provided additional information (ADC) as compared to STIR, T1 and T2 weighted images, supporting a more reliable lesion classification. DWIBS may serve as a valuable asset to the tools for characterizing cancer models in mice.