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Abstract #4828

Investigating δR1 and δR2* as Biomarkers of Tumour Oxygenation

Jake Samuel Burrell1, Jane Halliday2, Simon Walker-Samuel3, John C. Waterton2, Jessica Boult1, Yann Jamin1, Lauren C. Baker1, Simon P. Robinson1

1The Institute of Cancer Research, Sutton, Surrey, United Kingdom; 2AstraZeneca, Manchester, United Kingdom; 3UCL, London, United Kingdom

Carbogen-induced changes in R1, sensitive to dissolved paramagnetic molecular oxygen in the blood, and R2*, dependent on paramagnetic deoxyhaemoglobin, were determined in the same murine GH3 prolactinomas. Carbogen significantly increased R1 and reduced R2* in all tumours. A weak yet statistically significant positive correlation was determined between δR1 and δR2*. Tumour regions exhibiting a large reduction in R2* yet small δR1 may indicate hypoxic tumour tissue. The combined use of δR1 and δR2* may prove more informative for the assessment of tumour hypoxia.