Yang Guo1, Ning Jin1,2, Rachel Klein1, Guang-Yu Yang3, Reed Omary1,2, Andrew Larson1,2
1Department of Radiology, Northwestern University, Chicago, IL, United States; 2Department of Biomedical Engineering , Northwestern University, Chicago, IL, United States; 3Department of Pathology, Northwestern University, Chicago, IL, United States
Assessment of tumor necrosis is important for evaluating tumor treatment response. Gas-challenge (GC) blood oxygen level dependent (BOLD) MRI may permit tissue characterization without the need for exogenous contrast agents. For our study, we tested the feasibility of using GC-BOLD MRI to assess tumor necrosis fraction and compare to reference standard histological measurements in a rodent N1-S1 hepatoma model and found a significant positive correlation between gold-standard histology and GC-BOLD measured necrotic fraction. GC-BOLD MRI might serve as a non-invasive surrogate for early assessment of therapy response (prior to conventional anatomic size changes).