Caroline Diepart1, Julie Magat1,
Bndicte Jordan1, Bernard Gallez1
1UCL, Brussels, Belgium
this study, we developed a method based on 19F-MRI relaxometry for mapping
the oxygen consumption in tumors. The protocol was based on the measurement
of pO2 during a carbogen challenge protocol. The hyperthyroid mice provided
ideal models with tissues presenting differences in oxygen consumption rates.
The histogram of the 19F MRI data showed a shift to the higher oxygen
consumption rates for the hyperthyroid tumors. For each tumor, we obtained a
color map created from the 19F MRI data, reflecting the heterogeneity in
oxygen consumption. 19F-MRI relaxometry allows the non invasive mapping of
the oxygen consumption in tumors.