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Abstract #4982

MR Iron Quantification of Soluble (Ferritin-Like) and Insoluble (Hemosiderin-Like) Iron: A Biochemical Validation in Human Liver Explants

Christina Louise Tosti1, Boguslaw S. Wojczyk2, Sujit S. Sheth2, Daniel Kim3, Haiying Tang2, Jens H. Jensen3, Gary M. Brittenham2, Truman R. Brown2

1The Ohio State University, Columbus, OH, United States; 2Columbia University, New York, NY, United States; 3New York University, New York, NY, United States

A theoretical MR model has been proposed that separately quantifies dispersed (soluble, ferritin-like) and aggregated (insoluble, hemosiderin-like) iron by distinguishing their effects on R2 relaxation curves. In this study, we examine human liver explants with this non-invasive MR iron measurement technique. We compare the results of iron quantification using this model to the tissue concentrations of ferritin and hemosiderin iron determined by biochemical analysis.