Abstract #4982

MR Iron Quantification of Soluble (Ferritin-Like) and Insoluble (Hemosiderin-Like) Iron: A Biochemical Validation in Human Liver Explants

Christina Louise Tosti¹, Boguslaw S. Wojczyk², Sujit S. Sheth², Daniel Kim³, Haiying Tang², Jens H. Jensen³, Gary M. Brittenham², Truman R. Brown²

¹The Ohio State University, Columbus, OH, United States; ²Columbia University, New York, NY, United States; ³New York University, New York, NY, United States

A theoretical MR model has been proposed that separately quantifies dispersed (soluble, ferritin-like) and aggregated (insoluble, hemosiderin-like) iron by distinguishing their effects on R2 relaxation curves. In this study, we examine human liver explants with this non-invasive MR iron measurement technique. We compare the results of iron quantification using this model to the tissue concentrations of ferritin and hemosiderin iron determined by biochemical analysis.