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Abstract #4981

Cramer-Rao Lower Bounds for Assessment of Precision in T2* Value Evaluation by GRE Multiecho Sequence: Application to Iron Overload Measurements in Thalassemia Patients

Vincenzo Positano1, Luca Menichetti1, Alessia Pepe1, Antonella Meloni1, Daniele De Marchi1, Matteo Milanesi1, Maria Filomena Santarelli1, Giovanni Palazzi2, Massimo Lombardi1, Luigi Landini1,3

1MRI Lab, "G. Monasterio" Foundation and Institute of Clinical Physiology, Pisa, Italy; 2Oncoematologia Pediatrica, Policlinico di Modena, Modena, Italy; 3Department of Information Engineering, University of Pisa, Pisa, Italy

T2* multiecho magnetic resonance is an established methodology for assessment of iron overload in heart, liver, and other organs by evaluation of the T2* value. However, the dependence of the expected error from T2* value and acquisition parameters is unknown. This study demonstrate that evaluation of Cramer-Rao lower bounds allows to quantify the precision limits of T2* assessment for various schema of TEs. CRLB approach was applied to evaluate the T2* measurement quality in thalassemia patients.