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Abstract #4988

Fast Two-Dimensional Relaxometric Characterisation of Brain Tissue in Vivo: Is T1 Relaxation Multi-Component?

Ana-Maria Oros-Peusquens1, Fabian Keil1, N Jon Shah1,2

1Institute of Neuroscience and Medicine 4, Medical Imaging Physics, Forschungszentrum Juelich GmbH, Juelich, Germany; 2Faculty of Medicine, RWTH Aachen University, Aachen, Germany

T1 mapping is performed with a spoiled 3D multiple-echo gradient echo sequence, from two acquisitions with same TR and different flip angles. At each different echo time, an independent T1 map is produced. Apart from small variations due to decreasing SNR with echo time, no dependence of T1 on TE is expected from the theoretical description of the method. However, a systematic increase of T1 with echo time is observed in the white matter, and interpreted as an indication for multi-component T1 decay due to the presence of multiple and distinct water environments.