Ludovic de Rochefort1, Aurlie Delzor1, Martine Guillermier1, Diane Houitte1, Marion Chaigneau1, Nicole Dglon1, Philippe Hantraye1, Vincent Lebon1
1MIRCen, I2BM, DSV, CEA, Fontenay-aux-Roses, France
Molecular and cellular imaging is seeing a growing interest, but applicability to MRI relies on the ability to be specific, sensitive and quantifiable. Superparamagnetic iron oxides are good candidates as they produce a strong magnetic field creating signal voids in gradient echo images. Quantitative susceptibility mapping (QSM) additively uses the magnetic field to quantify the magnetic sources. In this study we apply QSM in the preclinical context of the rat brain using a reconstruction algorithm that includes unwrapping, removing background effects and inverting the field map. The technique demonstrates its ability to quantify SPIO amounts injected in the brain.